Phenotypes Associated with This Genotype

Genotype
MGI:4837144

• Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn; Tg(MMTV-cre)105Ayn/0
• Genetic Background: FVB.Cg-Trp53^tm1Brn Tg(MMTV-cre)105Ayn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:165292 )

• by 700 days, 8 of 16 mice develop mammary neoplasms

• however, mice do not exhibit lymphomas or other non-mammary neoplasms

increased carcinoma incidence ( J:165292 )

• 8 of 27 neoplasms are well-differentiated carcinomas

• while one tumor is an adenosquamous carcinoma the remaining tumors are poorly differentiated carcinomas with spindle or polygonal, frequently pleomorphic cells

increased squamous cell carcinoma incidence ( J:165292 )

• 1 adenosquamous carcinoma

increased lung tumor incidence ( J:165292 )

• 3 of 27 mice develop lung metastasis

integument

increased mammary gland tumor incidence ( J:165292 )

• by 700 days, 8 of 16 mice develop mammary neoplasms

• however, mice do not exhibit lymphomas or other non-mammary neoplasms

respiratory system

increased lung tumor incidence ( J:165292 )

• 3 of 27 mice develop lung metastasis

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:165292 )

• by 700 days, 8 of 16 mice develop mammary neoplasms

• however, mice do not exhibit lymphomas or other non-mammary neoplasms