Phenotypes Associated with This Genotype

Genotype
MGI:4837124

• Allelic Composition: Kcnh3^tm1.2Tije/Kcnh3^tm1.2Tije
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:165296 )

• pentylenetetrazol-treated mice exhibit reduced latency to seizure and increased seizure severity at threshold compared with similarly treated wild-type mice

nonconvulsive seizures ( J:165296 )

abnormal spike wave discharge ( J:165296 )

• mice exhibit a generalized pattern of sharp synchronous discharges unlike wild-type mice

abnormal single cell response ( J:165296 )

• at P2, neurons exhibit a depolarized resting membrane potentials, reduced firing threshold, and increased input resistance compared with wild-type neurons

• at P2, the interval between resting potential and firing threshold is compressed compared to in wild-type neurons

• at P2, steady state potassium ion current under voltage clamp at -20mV is reduced and neurons require less current to achieve a given spike frequency compared to in similarly treated wild-type neurons

• at 8 to 9 weeks of age, the interval between resting potential and threshold is compressed and maximal firing rate is reduced compared to in wild-type neurons

decreased single cell response threshold ( J:165296 )

behavior/neurological

behavior/neurological phenotype ( J:165296 )

N • mice exhibit normal motor coordination and learning, activity level and explorative behavior, and contextual and cued fear conditioning

increased susceptibility to pharmacologically induced seizures ( J:165296 )

• pentylenetetrazol-treated mice exhibit reduced latency to seizure and increased seizure severity at threshold compared with similarly treated wild-type mice

nonconvulsive seizures ( J:165296 )

abnormal spike wave discharge ( J:165296 )

• mice exhibit a generalized pattern of sharp synchronous discharges unlike wild-type mice