Phenotypes Associated with This Genotype

Genotype
MGI:4837002

• Allelic Composition: Dgkb^{Tn(sb-lacZ,GFP)IR3.PV122Jtak}/Dgkb^{Tn(sb-lacZ,GFP)IR3.PV122Jtak}
• Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal long-term spatial reference memory ( J:163104 )

• in contrast to wild-type mice which spent increased time in the old target quadrant, mice spent almost equal time in the four areas of the Morris water maze test

• mice swam further away from where the platform used to be than wild-type mice

abnormal spatial working memory ( J:163104 )

• a significant decrease in alternation compared to their wild-type litter mates in a Y-maze

nervous system

abnormal hippocampus neuron morphology ( J:163104 )

• in culture the number of branches, spines as well as total length of neurites and branches, is significantly decreased compared to wild-type

abnormal synapse morphology ( J:163104 )

• The average number of synaptic junctions detected by electron microscopy is decreased compared to wild-type

reduced long-term potentiation ( J:163104 )

• a marked reduction of LTP was observed in the CA1 region

homeostasis/metabolism

abnormal lipid level ( J:163104 )

• phosphatidic acid content is reduced to about 70% wild-type levels in the hippocampus