About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4836978
Allelic
Composition		 Hspa4tm1.1Miv/Hspa4tm1.1Miv
Tg(APPSWE)2576Kha/0
Genetic
Background		 involves: BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa4tm1.1Miv mutation (0 available); any Hspa4 mutation (75 available)
Tg(APPSWE)2576Kha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:164904 )
• many mice die before 7 months of age

nervous system
neurofibrillary tangles ( J:164904 )
• at 6 months, mice develop neurofibril tangles unlike Tg(APPSWE)2576Kha mice
• at 7 months, mice develop senility plaques unlike Tg(APPSWE)2576Kha mice
neurodegeneration ( J:164904 )
• neuron degeneration is more severe than in Tg(APPSWE)2576Kha mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory