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Phenotypes Associated with This Genotype
Genotype
MGI:4836978
Allelic
Composition		 Hspa4tm1.1Miv/Hspa4tm1.1Miv
Tg(APPSWE)2576Kha/0
Genetic
Background		 involves: BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa4tm1.1Miv mutation (0 available); any Hspa4 mutation (78 available)
Tg(APPSWE)2576Kha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:164904 )
• many mice die before 7 months of age

nervous system
neurofibrillary tangles ( J:164904 )
• at 6 months, mice develop neurofibril tangles unlike Tg(APPSWE)2576Kha mice
• at 7 months, mice develop senility plaques unlike Tg(APPSWE)2576Kha mice
neurodegeneration ( J:164904 )
• neuron degeneration is more severe than in Tg(APPSWE)2576Kha mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory