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Phenotypes Associated with This Genotype
Genotype
MGI:4836916
Allelic
Composition
Cxcr4tm1Yiw/Cxcr4tm1Yiw
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Yiw mutation (5 available); any Cxcr4 mutation (50 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers
• thymocytes numbers are significantly reduced

immune system
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers
• thymocytes numbers are significantly reduced
• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

skeleton
• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

cellular
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers

endocrine/exocrine glands
• thymocytes numbers are significantly reduced


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory