Phenotypes Associated with This Genotype

Genotype
MGI:4836580

• Allelic Composition: Plau^tm1.1Bug/Plau^tm1.1Bug
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

chronic inflammation ( J:164542 )

• chronic inflammation is secondary to fibrin deposition

liver inflammation ( J:164542 )

• the number of inflammatory foci is increased 4-fold compared to in wild-type mice

trachea inflammation ( J:164542 )

• 2 of 9 mice exhibit mild to moderate inflammation of the trachea unlike wild-type mice

liver/biliary system

liver inflammation ( J:164542 )

• the number of inflammatory foci is increased 4-fold compared to in wild-type mice

liver fibrosis ( J:164542 )

respiratory system

trachea inflammation ( J:164542 )

• 2 of 9 mice exhibit mild to moderate inflammation of the trachea unlike wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:164542 )

N • skin wound healing is normal

decreased physiological sensitivity to xenobiotic ( J:164542 )

• mice treated with a modified anthrax toxin that requires proteolytic activation by Plau are unaffected unlike similarly treated wild-type mice