Phenotypes Associated with This Genotype

Genotype
MGI:4836384

• Allelic Composition: Grhl2^tm1.1Jane/Grhl2^tm1.1Jane
• Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:164805 )

• die at approximately E11.5

nervous system

incomplete caudal neuropore closure ( J:164805 )

• the posterior neuropore remains open at E10.5

craniofacial

cranioschisis ( J:164805 )

facial cleft ( J:164805 )

• fully penetrant split face malformation

embryo

abnormal neural fold elevation formation ( J:164805 )

• the dorso-lateral hinge points fail to form in the cephalic region by the 15 - 25 somite stage

• however, in areas of the spinal cord above the neural tube defect dorso-lateral hinge formation is seen

incomplete caudal neuropore closure ( J:164805 )

• the posterior neuropore remains open at E10.5

skeleton

cranioschisis ( J:164805 )

growth/size/body

facial cleft ( J:164805 )

• fully penetrant split face malformation