Phenotypes Associated with This Genotype

Genotype
MGI:4836377

• Allelic Composition: Tg(Camk2a-AIDPak)21Stl/0
• Genetic Background: C57BL/6-Tg(Camk2a-AIDPak)21Stl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:90763 )

N • the ratio of NMDAR to AMPAR mediated synaptic currents is normal

abnormal dendritic spine morphology ( J:90763 )

• the density of dendritic spines is lower in layer II/III of the temporal cortex compared to in wild-type mice

• cortical neurons exhibit shorter spine length compared with wild-type neurons

• however, dendritic length and number of branch point are normal and hippocampal CA1 pyramidal neurons exhibit normal dendritic spine density, dendritic length, and branch point numbers are normal

abnormal synapse morphology ( J:90763 )

• mice exhibit an increase in the proportion of larger synapses compared with wild-type mice

abnormal synaptic vesicle number ( J:90763 )

• the number of docked vesicles per bouton is greater than in wild-type neurons

• however, the density of docked vesicles is normal

enhanced long-term potentiation ( J:90763 )

abnormal miniature excitatory postsynaptic currents ( J:90763 )

• the mean amplitude of AMPAR-mediated miniature excitatory postsynaptic currents (mEPSCs) is greater than in wild-type mice

• however, the mean frequency of AMPAR-mediated mEPSCs is normal

reduced long-term depression ( J:90763 )

behavior/neurological

impaired contextual conditioning behavior ( J:90763 )

• 24 hours after training

abnormal long-term spatial reference memory ( J:90763 )

• in a hidden-platform Morris water maze 21 days after training, mice exhibit impaired consolidation/retention of spatial memory compared with wild-type mice

• however, acquisition of spatial memory is normal