Phenotypes Associated with This Genotype

Genotype
MGI:4835052

• Allelic Composition: f/f
• Genetic Background: involves: CBA/St

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:164714 )

• early postnatal depletion of homozygous animals

hematopoietic system

anemia ( J:164714 , J:14979 )

• first evident at embryonic day 12 (J:14979)

hypochromic anemia ( J:164714 )

• although the mean red blood cell size is normal, the hemoglobin concentration is reduced, there are fewer red blood cells and this transitory anemia is most significant embryonically and at birth then wanes during the first few weeks of life

decreased mean corpuscular hemoglobin ( J:164714 )

increased siderocyte number ( J:14979 )

• the majority of red blood cells in newborns are siderocytes, which are incompletely haemoglobinized as evidenced by faint color and weak stain uptake

• the percentage of siderocytes decreases from 80% at birth to approximately 40% at 1 week of age and stabilizes at approximately 3% by 3 weeks of age persisting at this higher than normal level in the adult

reticulocytosis ( J:164714 )

• striking reticulocytosis at birth and reticulocyte count remains high at 13 days of age but decreases by 3 weeks of age as the anemia resolves

integument

pallor ( J:14979 )

• homozygotes are recognizably paler than normal from embryonic day 16 onward and most can be identified this way as early as embryonic day 15