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Phenotypes Associated with This Genotype
Genotype
MGI:4834591
Allelic
Composition
Fgatm1Jld/Fgatm1Jld
Vwftm1Wgr/Vwftm1Wgr
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgatm1Jld mutation (0 available); any Fga mutation (44 available)
Vwftm1Wgr mutation (1 available); any Vwf mutation (138 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 23% of mice die before weaning

homeostasis/metabolism
• after FeCl3 treatment, platelet interaction with the vessel wall is delayed and platelet deposition is less than in similarly treated wild-type mice
• thrombi that form in FeCl3-treated mice fail to resist sheer stress and eventually break off unlike in similarly treated wild-type mice
• FeCl3-induced thrombi are more fragile than in similarly treated wild-type mice or Fgatm1Jld homozygotes
• FeCl3-treated mice exhibit shorter occlusion times compared with similarly treated Vwftm1Wgr homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory