Phenotypes Associated with This Genotype

Genotype
MGI:4834581

• Allelic Composition: Mbp^shi/Mbp^shi; Tg(Thy1-YFP)HJrs/0
• Genetic Background: involves: C3HeB/Fe * C57BL/6 * CBA * SWV

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:158545 )

• following treatment with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), seizures are more frequent and last longer than in similarly treated wild-type mice

increased susceptibility to neuronal excitotoxicity ( J:158545 )

• mice treated with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) exhibit increased axonal damage, excitotoxicity, and behavioral deficits (including seizures, hindlimb and tail paresis, impaired coordination) compared with similarly treated wild-type mice

• however, activation of the N-methyl-D-aspartic acid (NMDA) receptors does not result in axonal injury

abnormal myelination ( J:158545 )

• dorsal columns lack myelin unlike in wild-type mice

• mice exhibit amyelinated and hypomyelinated axons unlike in wild-type mice

demyelination ( J:158545 )

• mice exhibit amyelinated and hypomyelinated axons unlike in wild-type mice

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:158545 )

• following treatment with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), seizures are more frequent and last longer than in similarly treated wild-type mice

impaired coordination ( J:158545 )

• on a rotarod at baseline and after treatment with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)

paresis ( J:158545 )

• hindlimb and tail paresis following treatment with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:158545 )

• mice treated with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) exhibit increased axonal damage, excitotoxicity, and behavioral deficits (including seizures, hindlimb and tail paresis, impaired coordination) compared with similarly treated wild-type mice

• however, activation of the N-methyl-D-aspartic acid (NMDA) receptors does not result in axonal injury

cellular

increased susceptibility to neuronal excitotoxicity ( J:158545 )

• mice treated with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) exhibit increased axonal damage, excitotoxicity, and behavioral deficits (including seizures, hindlimb and tail paresis, impaired coordination) compared with similarly treated wild-type mice

• however, activation of the N-methyl-D-aspartic acid (NMDA) receptors does not result in axonal injury