Phenotypes Associated with This Genotype

Genotype
MGI:4834472

• Allelic Composition: Lck^tm1Mak/Lck^tm1Mak
• Genetic Background: B6.129S2-Lck^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell morphology ( J:111646 )

• in reconstitution experiments, intrathymic development of intestinal intraepithelial lymphocytes (iIELs) is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell number ( J:111646 )

• at 10 weeks, the number of intestinal intraepithelial lymphocytes (iIELs) is increased 1.5- to 2-fold compared to in wild-type mice

• the number of iIELs decrease over time unlike in wild-type mice that exhibit an increase in these cells

decreased gamma-delta intraepithelial T cell number ( J:111646 )

• at 10 weeks, mice exhibit decreased gamma-delta intestinal intraepithelial lymphocytes, which continue to decrease in number with age, compared with wild-type mice

decreased cytotoxic T cell cytolysis ( J:111646 )

• intestinal intraepithelial lymphocytes exhibit a slight reduction in cytolytic activities compared with wild-type cells

hematopoietic system

abnormal T cell differentiation ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell morphology ( J:111646 )

• in reconstitution experiments, intrathymic development of intestinal intraepithelial lymphocytes (iIELs) is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell number ( J:111646 )

• at 10 weeks, the number of intestinal intraepithelial lymphocytes (iIELs) is increased 1.5- to 2-fold compared to in wild-type mice

• the number of iIELs decrease over time unlike in wild-type mice that exhibit an increase in these cells

decreased gamma-delta intraepithelial T cell number ( J:111646 )

• at 10 weeks, mice exhibit decreased gamma-delta intestinal intraepithelial lymphocytes, which continue to decrease in number with age, compared with wild-type mice

decreased cytotoxic T cell cytolysis ( J:111646 )

• intestinal intraepithelial lymphocytes exhibit a slight reduction in cytolytic activities compared with wild-type cells