Phenotypes Associated with This Genotype

Genotype
MGI:4834471

• Allelic Composition: Ptprc^tm1Mak/Ptprc^tm1Mak
• Genetic Background: B6.Cg-Ptprc^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) exhibit increased spontaneous apoptosis compared to in wild-type mice

• gamma-delta iIELs are more susceptible to induction of apoptosis compared with alpha-beta iIELs

abnormal T cell differentiation ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell morphology ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) are slightly larger than wild-type cells

• in reconstitution experiments, intrathymic development of iIELs is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell number ( J:111646 )

• at 10 weeks, the number of intestinal intraepithelial lymphocytes (iIELs) is increased 1.5- to 2-fold compared to in wild-type mice

• at 10 weeks, the number of CD4+CD8- alpha-beta iIELs is increased 7-fold compared to in wild-type mice

• the number of iIELs decrease over time unlike in wild-type mice that exhibit an increase in these cells

• at 20 weeks, iIELs are decreased compared to in wild-type mice

decreased gamma-delta intraepithelial T cell number ( J:111646 )

• at 10 and 20 weeks, mice exhibit decreased gamma-delta intestinal intraepithelial lymphocytes, which continue to decrease in number with age, compared with wild-type mice

abnormal CD4-positive, alpha-beta intraepithelial T cell morphology ( J:111646 )

• at 10 weeks, the number of CD4+CD8- alpha-beta intestinal intraepithelial lymphocytes is increased 7-fold compared to in wild-type mice

abnormal NK cell physiology ( J:109462 )

• NK cells stimulated with ligands to or antibodies against NK1.1, CD16, Ly49H, Ly49D, and NKG2D exhibit reduced cytokine secretion compared with similarly treated wild-type cells

• however, NK cell cytotoxicity in response to ITAM receptor stimulation is normal

decreased cytotoxic T cell cytolysis ( J:111646 )

• intestinal intraepithelial lymphocytes exhibit impaired cytolytic activities compared with wild-type cells

hematopoietic system

increased T cell apoptosis ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) exhibit increased spontaneous apoptosis compared to in wild-type mice

• gamma-delta iIELs are more susceptible to induction of apoptosis compared with alpha-beta iIELs

abnormal T cell differentiation ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell morphology ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) are slightly larger than wild-type cells

• in reconstitution experiments, intrathymic development of iIELs is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell number ( J:111646 )

• at 10 weeks, the number of intestinal intraepithelial lymphocytes (iIELs) is increased 1.5- to 2-fold compared to in wild-type mice

• at 10 weeks, the number of CD4+CD8- alpha-beta iIELs is increased 7-fold compared to in wild-type mice

• the number of iIELs decrease over time unlike in wild-type mice that exhibit an increase in these cells

• at 20 weeks, iIELs are decreased compared to in wild-type mice

decreased gamma-delta intraepithelial T cell number ( J:111646 )

• at 10 and 20 weeks, mice exhibit decreased gamma-delta intestinal intraepithelial lymphocytes, which continue to decrease in number with age, compared with wild-type mice

abnormal CD4-positive, alpha-beta intraepithelial T cell morphology ( J:111646 )

• at 10 weeks, the number of CD4+CD8- alpha-beta intestinal intraepithelial lymphocytes is increased 7-fold compared to in wild-type mice

abnormal NK cell physiology ( J:109462 )

• NK cells stimulated with ligands to or antibodies against NK1.1, CD16, Ly49H, Ly49D, and NKG2D exhibit reduced cytokine secretion compared with similarly treated wild-type cells

• however, NK cell cytotoxicity in response to ITAM receptor stimulation is normal

decreased cytotoxic T cell cytolysis ( J:111646 )

• intestinal intraepithelial lymphocytes exhibit impaired cytolytic activities compared with wild-type cells

cellular

increased T cell apoptosis ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) exhibit increased spontaneous apoptosis compared to in wild-type mice

• gamma-delta iIELs are more susceptible to induction of apoptosis compared with alpha-beta iIELs