Phenotypes Associated with This Genotype

Genotype
MGI:4834358

• Allelic Composition: Zmpste24^tm1Otin/Zmpste24^tm1Otin
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:164373 )

• however, treatment with recombinant IGF1 improves premature aging symptoms

premature aging ( J:164373 )

• mice exhibit premature signs of aging (including decreased body weight and subcutaneous fat, kyphosis, alopecia, and premature death) compared with wild-type mice

• however, treatment with recombinant IGF1 improves premature aging symptoms

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:164373 )

• beginning at 1 month of age and declining progressively with age

increased circulating growth hormone level ( J:164373 )

• 5- and 11-fold at 2 and 4 months of age

• however, treatment with recombinant IGF1 improves GH serum levels

adipose tissue

decreased subcutaneous adipose tissue amount ( J:164373 )

• however, treatment with recombinant IGF1 improves premature aging symptoms

growth/size/body

decreased body weight ( J:164373 )

• however, treatment with recombinant IGF1 improves premature aging symptoms

skeleton

kyphosis ( J:164373 )

• however, treatment with recombinant IGF1 improves premature aging symptoms

integument

decreased subcutaneous adipose tissue amount ( J:164373 )

• however, treatment with recombinant IGF1 improves premature aging symptoms

alopecia ( J:164373 )

• however, treatment with recombinant IGF1 improves premature aging symptoms

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
progeria		DOID:3911	OMIM:176670	J:164373