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Phenotypes Associated with This Genotype
Genotype
MGI:4834358
Allelic
Composition
Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zmpste24tm1Otin mutation (0 available); any Zmpste24 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• however, treatment with recombinant IGF1 improves premature aging symptoms
• mice exhibit premature signs of aging (including decreased body weight and subcutaneous fat, kyphosis, alopecia, and premature death) compared with wild-type mice
• however, treatment with recombinant IGF1 improves premature aging symptoms

homeostasis/metabolism
• beginning at 1 month of age and declining progressively with age
• 5- and 11-fold at 2 and 4 months of age
• however, treatment with recombinant IGF1 improves GH serum levels

adipose tissue
• however, treatment with recombinant IGF1 improves premature aging symptoms

growth/size/body
• however, treatment with recombinant IGF1 improves premature aging symptoms

skeleton
• however, treatment with recombinant IGF1 improves premature aging symptoms

integument
• however, treatment with recombinant IGF1 improves premature aging symptoms
• however, treatment with recombinant IGF1 improves premature aging symptoms

Mouse Models of Human Disease
OMIM ID Ref(s)
Hutchinson-Gilford Progeria Syndrome; HGPS 176670 J:164373


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory