Mouse Genome Informatics
hm
    Zmpste24tm1Otin/Zmpste24tm1Otin
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• however, treatment with recombinant IGF1 improves premature aging symptoms
• mice exhibit premature signs of aging (including decreased body weight and subcutaneous fat, kyphosis, alopecia, and premature death) compared with wild-type mice
• however, treatment with recombinant IGF1 improves premature aging symptoms

homeostasis/metabolism
• beginning at 1 month of age and declining progressively with age
• 5- and 11-fold at 2 and 4 months of age
• however, treatment with recombinant IGF1 improves GH serum levels

adipose tissue
• however, treatment with recombinant IGF1 improves premature aging symptoms

growth/size/body
• however, treatment with recombinant IGF1 improves premature aging symptoms

skeleton
• however, treatment with recombinant IGF1 improves premature aging symptoms

integument
• however, treatment with recombinant IGF1 improves premature aging symptoms
• however, treatment with recombinant IGF1 improves premature aging symptoms

Mouse Models of Human Disease
OMIM IDRef(s)
Hutchinson-Gilford Progeria Syndrome; HGPS 176670 J:164373