Phenotypes Associated with This Genotype

Genotype
MGI:4834266

• Allelic Composition: Tg(TcraTcrb)425Cbn/0; Trip10^tm1.1Geha/Trip10^tm1.1Geha
• Genetic Background: B6.Cg-Trip10^tm1.1Geha Tg(TcraTcrb)425Cbn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:164363 )

N • oxazalone-treated mice exhibit normal antigen-specific T effector cell generation

abnormal effector T cell morphology ( J:164363 )

• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred

decreased CD4-positive, alpha-beta T cell number ( J:164363 )

• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used

hematopoietic system

abnormal effector T cell morphology ( J:164363 )

• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred

decreased CD4-positive, alpha-beta T cell number ( J:164363 )

• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used