Phenotypes Associated with This Genotype

Genotype
MGI:4833965

• Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx; Tg(Thy1-APP)3Somm/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:134832 )

N • at 24 months, mice exhibit little neuronal loss unlike Tg(Thy1-APP)3Somm mice

microgliosis ( J:134832 )

• mice exhibit less microglial activation compared with Tg(Thy1-APP)3Somm mice

amyloid beta deposits ( J:134832 )

• at 24 months, mice exhibit reduced amyloid plaques compared with Tg(Thy1-APP)3Somm mice

cerebral amyloid angiopathy ( J:134832 )

• mice exhibit reduced cerebral amyloid angiopathy compared with Tg(Thy1-APP)3Somm mice

behavior/neurological

behavior/neurological phenotype ( J:134832 )

N • mice exhibit normal exploratory learning and memory retention unlike Tg(Thy1-APP)3Somm mice

hematopoietic system

microgliosis ( J:134832 )

• mice exhibit less microglial activation compared with Tg(Thy1-APP)3Somm mice

immune system

microgliosis ( J:134832 )

• mice exhibit less microglial activation compared with Tg(Thy1-APP)3Somm mice

homeostasis/metabolism

amyloid beta deposits ( J:134832 )

• at 24 months, mice exhibit reduced amyloid plaques compared with Tg(Thy1-APP)3Somm mice

cerebral amyloid angiopathy ( J:134832 )

• mice exhibit reduced cerebral amyloid angiopathy compared with Tg(Thy1-APP)3Somm mice