Phenotypes for Apoe Ccr2 Cx3cl1 MGI:4833678 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^tm1Ifc Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
Genetic Background	B6.Cg-Apoe^tm1Unc Cx3cl1^tm1Lira Ccr2^tm1Ifc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (35 available); any Apoe mutation (164 available)
Ccr2^tm1Ifc mutation (1 available); any Ccr2 mutation (44 available)
Cx3cl1^tm1Lira mutation (0 available); any Cx3cl1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:153310 )

• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoe^tm1Unc homozygotes and Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

hematopoietic system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

immune system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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