Phenotypes Associated with This Genotype

Genotype
MGI:4831169

• Allelic Composition: Ccr2^tm1Ifc/Ccr2^tm1Ifc; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:121703 )

• by 130 days, 85% of mice are dead compared with 30% of mice expressing Tg(APPSWE)2576Kha, 1% of wild-type mice, and 3% of Ccr2^tm1Ifc homozygotes

nervous system

intracranial hemorrhage ( J:121703 )

abnormal microglial cell physiology ( J:121703 )

• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha

• however, microglial proliferation and responses to beta-amyloid are normal

amyloid beta deposits ( J:121703 )

• at P65 without classic plaques

immune system

abnormal microglial cell physiology ( J:121703 )

• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha

• however, microglial proliferation and responses to beta-amyloid are normal

cardiovascular system

intracranial hemorrhage ( J:121703 )

hematopoietic system

abnormal microglial cell physiology ( J:121703 )

• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha

• however, microglial proliferation and responses to beta-amyloid are normal

homeostasis/metabolism

amyloidosis ( J:121703 )

• at P65, accumulation of beta-amyloid 1-42 and 1-40 in the brain are 2.4-fold and 1.4-fold respectively compared to in mice expressing Tg(APPSWE)2576Kha

amyloid beta deposits ( J:121703 )

• at P65 without classic plaques

cellular

abnormal microglial cell physiology ( J:121703 )

• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha

• however, microglial proliferation and responses to beta-amyloid are normal