Phenotypes for Apoe Ccr2 MGI:4831159 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (34 available); any Apoe mutation (163 available)
Ccr2^tm1Ifc mutation (1 available); any Ccr2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:111471 )

• atherosclerotic lesions in mice fed a high fat diet for 5 weeks are smaller than in similarly treated Apoe^tm1Unc homozygotes

• however, no difference was observed at later time points

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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