About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4831158
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in mice fed a high fat diet for 5, 9, and 13 weeks, atherosclerotic lesions are smaller than in similarly treated Apoetm1Unc homozygotes
• however, serum cholesterol levels are the same as in Apoetm1Unc homozygotes

immune system
• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoetm1Unc homozygotes

cellular
• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoetm1Unc homozygotes

hematopoietic system
• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoetm1Unc homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory