Phenotypes Associated with This Genotype

Genotype
MGI:4831151

• Allelic Composition: Insr^tm1Dac/Insr^tm1Dac; Tg(TTR-INSR)L3Dac/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:91350 )

• die between 3 weeks and 8 months

growth/size/body

decreased birth weight ( J:91350 )

• weight is 60% of controls

postnatal growth retardation ( J:91350 )

• remain growth retarded throughout life

enlarged liver ( J:91350 )

• hepatomegaly

adipose tissue

decreased white adipose tissue amount ( J:91350 )

• lack white adipose tissue

liver/biliary system

enlarged liver ( J:91350 )

• hepatomegaly

decreased liver glycogen level ( J:91350 )

hepatic steatosis ( J:91350 )

liver degeneration ( J:91350 )

• fatty liver degeneration

abnormal liver physiology ( J:91350 )

homeostasis/metabolism

increased circulating glucose level ( J:91350 )

• diabetic at 2 months

hyperglycemia ( J:91350 )

• by four weeks

increased circulating insulin level ( J:91350 )

decreased liver glycogen level ( J:91350 )

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:91350 )

• extensive loss of insulin positive cells at 4 months

increased pancreatic beta cell mass ( J:91350 )

• increased 3 fold

reproductive system

female infertility ( J:91350 )

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