Phenotypes Associated with This Genotype

Genotype
MGI:4831149

• Allelic Composition: Insr^tm1Dac/Insr^tm1Dac; Tg(TTR-INSR)L1Dac/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased birth weight ( J:91350 )

• weigh 80% of control mice

increased growth rate ( J:91350 )

• limited recovery from low birth weight

homeostasis/metabolism

increased circulating glucose level ( J:91350 )

• glucose levels remain normal in 90% of mice at 2 months of age

• 35% are diabetic at 6 months

• life spans remain normal

increased circulating insulin level ( J:91350 )

increased energy expenditure ( J:91350 )

• 10% increase in resting energy expenditure

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:91350 )

• moderately decreased

• islets are otherwise normal

reproductive system

reproductive system phenotype ( J:91350 )

N • normal fertility