Phenotypes Associated with This Genotype

Genotype
MGI:4831132

• Allelic Composition: Ccr2^tm1Ifc/Ccr2^tm1Ifc
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage chemotaxis ( J:44345 )

• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice

• however, the number of resident macrophage in mice is normal

impaired macrophage chemotaxis ( J:44345 , J:81363 , J:121703 )

• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells (J:44345)

• however, migration in response to MIP-1alpha is normal (J:44345)

• following injection of [3H]FC cat LDL into muscles (J:81363)

• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells (J:121703)

• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal (J:121703)

decreased T cell proliferation ( J:75838 )

• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice

decreased splenocyte proliferation ( J:75838 )

• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice

• however, proliferation in response to ConA or anti-CD3 antibodies is normal

abnormal microglial cell physiology ( J:121703 )

• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice

abnormal Langerhans cell physiology ( J:112594 )

• Langerhan cell repopulation after skin irradiation is impaired in these mice

abnormal immune serum protein physiology ( J:118971 )

decreased interferon-gamma secretion ( J:44345 , J:75838 )

• in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis (J:44345)

• in splenocytes treated with ConA (J:44345)

• in T cells and splenocytes from MOGp35-55 treated mice (J:75838)

increased interferon-gamma secretion ( J:61542 )

• in the livers of mice subjected to acute challenge with acetaminophen (APAP)

decreased interleukin-2 secretion ( J:44345 )

• in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis

decreased interleukin-6 secretion ( J:75838 )

• in splenocytes from MOGp35-55 treated mice

increased tumor necrosis factor secretion ( J:61542 )

• in the livers of mice subjected to acute challenge with acetaminophen (APAP)

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:75838 )

• MOGp35-55-treated mice fail to develop experimental autoimmune encephalomyelitis and exhibit no increase in chemokine production, reduced T cell and splenocyte proliferation, decreased IL6 production in splenocytes, and reduced IFN-gamma production in T cells and splenocytes compared with similarly treated wild-type mice

• however, monocyte recruitment in mice immunized with CFA beads is normal

decreased inflammatory response ( J:44345 )

• mice exposed to purified protein derivative (PPD) of Mycobacterium bovis produce smaller granulomas with fewer macrophages, no monocytosis, and decreased IFN-gamma and IL2 production compared with similarly treated wild-type mice

decreased susceptibility to type I hypersensitivity reaction ( J:118971 )

• mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response, increased lung MCP-1 levels, and no histamine release compared with similarly treated wild-type mice

• mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice

• however, eosinophil accumulation is normal

homeostasis/metabolism

increased circulating alanine transaminase level ( J:61542 )

• 120-fold above baseline in mice subjected to acute challenge with acetaminophen (APAP)

abnormal lipid homeostasis ( J:81363 )

• although serum levels of total and HDL cholesterol and phospholipids are slightly lower than in wild-type mice the difference was not statistically significant

abnormal cholesterol homeostasis ( J:81363 )

• cholesterol egress from muscles injected with [3H]FC cat LDL is slower than in similarly treated wild-type muscle due to a decrease in cholesteryl ester hydrolysis

increased physiological sensitivity to xenobiotic ( J:61542 )

• mice subjected to acute challenge with acetaminophen (APAP) exhibit liver necrosis/apoptosis, liver hemorrhage, and increased hepatic MCP-1, IFN-gamma, and TNF-alpha levels compared with similarly treated wild-type mice

• however, IL13 hepatic production in response to APAP is normal and immunoneutralization of IFN-gamma or TNF-alpha attenuates hepatotoxicity induced by APAP

liver/biliary system

liver hemorrhage ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

increased hepatocyte apoptosis ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

hepatic necrosis ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

cardiovascular system

liver hemorrhage ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

respiratory system

decreased airway responsiveness ( J:118971 )

• mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response compared with similarly treated wild-type mice

• mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice

hematopoietic system

abnormal macrophage chemotaxis ( J:44345 )

• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice

• however, the number of resident macrophage in mice is normal

impaired macrophage chemotaxis ( J:44345 , J:81363 , J:121703 )

• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells (J:44345)

• however, migration in response to MIP-1alpha is normal (J:44345)

• following injection of [3H]FC cat LDL into muscles (J:81363)

• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells (J:121703)

• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal (J:121703)

decreased T cell proliferation ( J:75838 )

• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice

decreased splenocyte proliferation ( J:75838 )

• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice

• however, proliferation in response to ConA or anti-CD3 antibodies is normal

decreased common myeloid progenitor cell number ( J:44345 )

• colony-forming unit granulocyte macrophage fail to form in response to mJE and hMCP-1 stimulation of bone marrow cells unlike similarly treated wild-type cells

• however, the number of progenitor cells in the marrow, spleen, and peripheral blood is normal

abnormal microglial cell physiology ( J:121703 )

• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice

nervous system

abnormal microglial cell physiology ( J:121703 )

• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice

cellular

increased hepatocyte apoptosis ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

hepatic necrosis ( J:61542 )

• in mice subjected to acute challenge with acetaminophen (APAP)

abnormal macrophage chemotaxis ( J:44345 )

• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice

• however, the number of resident macrophage in mice is normal

impaired macrophage chemotaxis ( J:44345 , J:81363 , J:121703 )

• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells (J:44345)

• however, migration in response to MIP-1alpha is normal (J:44345)

• following injection of [3H]FC cat LDL into muscles (J:81363)

• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells (J:121703)

• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal (J:121703)

decreased T cell proliferation ( J:75838 )

• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice

decreased splenocyte proliferation ( J:75838 )

• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice

• however, proliferation in response to ConA or anti-CD3 antibodies is normal