Mouse Genome Informatics
ot
    Dp(2Csrp2bp-6330439K17Rik)1Bra/0
D2.129-Dp(2Csrp2bp-6330439K17Rik)1Bra
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Eye abnormalities in Dp(2Csrp2bp-6330439K17Rik)1Bra/0 mice

vision/eye
• at P3, the cells in the iridocorneal angle are more densely packed than in wild-type mice
• at P5, the iridocorneal angle is occluded compared to in wild-type mice
• however, the irridocorneal angle is normal immediately after birth
• the trabecular meshwork of the eye is occluded by multilayered, stratified endothelial cells that exhibit an epithelial morphology, are visible in the iridocorneal angle and on the posterior surface of the cornea and anterior surface of the iris, and migrate onto the central cornea unlike in wild-type mice
• anterior
• mice exhibit inappropriate cytokeratin AE1/AE3 immunoreactivity in the corneal endothelium and iridocorneal angle, extending onto the anterior surface of the iris and posterior surface of the cornea unlike in wild-type mice
• mice exhibit lens subluxation and proliferation of cells over the surface of the lens unlike wild-type mice
• eye diameter is increased compared to in wild-type mice

cardiovascular system

Mouse Models of Human Disease
OMIM IDRef(s)
Corneal Dystrophy, Posterior Polymorphous, 1; PPCD1 122000 J:164007