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Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(2Csrp2bp-Dzank1)1Bra mutation (1 available); any Dp(2Csrp2bp-Dzank1)1Bra mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Eye abnormalities in Dp(2Csrp2bp-Dzank1)1Bra/0 mice

• at P3, the cells in the iridocorneal angle are more densely packed than in wild-type mice
• at P5, the iridocorneal angle is occluded compared to in wild-type mice
• however, the irridocorneal angle is normal immediately after birth
• the trabecular meshwork of the eye is occluded by multilayered, stratified endothelial cells that exhibit an epithelial morphology, are visible in the iridocorneal angle and on the posterior surface of the cornea and anterior surface of the iris, and migrate onto the central cornea unlike in wild-type mice
• mice exhibit inappropriate cytokeratin AE1/AE3 immunoreactivity in the corneal endothelium and iridocorneal angle, extending onto the anterior surface of the iris and posterior surface of the cornea unlike in wild-type mice
• mice exhibit lens subluxation and proliferation of cells over the surface of the lens unlike wild-type mice
• eye diameter is increased compared to in wild-type mice

cardiovascular system

Mouse Models of Human Disease
OMIM ID Ref(s)
Corneal Dystrophy, Posterior Polymorphous, 1; PPCD1 122000 J:164007

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory