Phenotypes Associated with This Genotype

Genotype
MGI:4830892

• Allelic Composition: Ppcd1/+
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Eye abnormalities in Ppcd1/0 mice

vision/eye

vision/eye phenotype ( J:164007 )

N • mice backcrossed to C57BL/6 for 3 generations do not exhibit the Corneal Dystrophy, Posterior Polymorphous, 1 (PPCD1) phenotype

posterior iris synechia ( J:164007 )

abnormal cornea morphology ( J:164007 )

• mice exhibit corneal haze, neovascularization, ulcers, and scarring unlike wild-type mice

cornea vascularization ( J:164007 )

anterior iris synechia ( J:164007 )

cornea opacity ( J:164007 )

cornea scarring ( J:164007 )

cornea ulcer ( J:164007 )

enlarged eye anterior chamber ( J:164007 )

• the anterior chamber is deep and enlarged compared to in wild-type mice

abnormal lens morphology ( J:164007 )

• mice exhibit lens subluxation unlike wild-type mice

phthisis bulbi ( J:164007 )

cardiovascular system

cornea vascularization ( J:164007 )