Mouse Genome Informatics
ot
    Htr2ctm1.1Eme/Y
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• Background Sensitivity: on a predominantly 129S6/SvEvTac background,10% to 20% of mice die between P21 and P24 (J:163043)
• Background Sensitivity: in a cross with a C57BL/6J male, 75% of mice die between P8 and P12 with none surviving beyond P15 (J:163043)
• however, mortality can be minimized by feeding wet food paste on a predominantly 129S6/SvEvTac background (J:163043)

behavior/neurological
• gastric milk content is decreased compared to in wild-type mice (J:163043)
• in adult mice when food consumption is corrected for weight (J:163043)
• in weanlings (P2-P28) but not adults on a rotarod (J:163043)
• in weanlings (P2-P28) but not adults (J:163043)
(J:163043)

growth/size/body
• at P21 despite normal birth weight (J:163043)
• mice fail to thrive after birth (J:163043)
• however, mice exhibit normal growth rate after weaning (J:163043)

homeostasis/metabolism
• total and resting energy adjusted for body weight are increased compared to in wild-type mice (J:163043)
(J:163043)

muscle
(J:163043)

pigmentation
(J:163043)

integument
(J:163043)

Mouse Models of Human Disease
OMIM IDRef(s)
Prader-Willi Syndrome; PWS 176270 J:163043