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Phenotypes Associated with This Genotype
Genotype
MGI:4830462
Allelic
Composition
Htr2ctm1.1Eme/Y
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1.1Eme mutation (0 available); any Htr2c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: on a predominantly 129S6/SvEvTac background,10% to 20% of mice die between P21 and P24 (J:163043)
• Background Sensitivity: on a predominantly 129S6/SvEvTac background,10% to 20% of mice die between P21 and P24 (J:163043)
• Background Sensitivity: in a cross with a C57BL/6J male, 75% of mice die between P8 and P12 with none surviving beyond P15 (J:163043)
• however, mortality can be minimized by feeding wet food paste on a predominantly 129S6/SvEvTac background (J:163043)
• Background Sensitivity: in a cross with a C57BL/6J male, 75% of mice die between P8 and P12 with none surviving beyond P15 (J:163043)
• however, mortality can be minimized by feeding wet food paste on a predominantly 129S6/SvEvTac background (J:163043)

behavior/neurological
• gastric milk content is decreased compared to in wild-type mice (J:163043)
• gastric milk content is decreased compared to in wild-type mice (J:163043)
• in adult mice when food consumption is corrected for weight (J:163043)
• in adult mice when food consumption is corrected for weight (J:163043)
(J:163043)
(J:163043)
• in weanlings (P2-P28) but not adults on a rotarod (J:163043)
• in weanlings (P2-P28) but not adults on a rotarod (J:163043)
• in weanlings (P2-P28) but not adults (J:163043)
• in weanlings (P2-P28) but not adults (J:163043)
(J:163043)
(J:163043)

growth/size/body
• at P21 despite normal birth weight (J:163043)
• at P21 despite normal birth weight (J:163043)
(J:163043)
(J:163043)
• mice fail to thrive after birth (J:163043)
• however, mice exhibit normal growth rate after weaning (J:163043)
• mice fail to thrive after birth (J:163043)
• however, mice exhibit normal growth rate after weaning (J:163043)

homeostasis/metabolism
• total and resting energy adjusted for body weight are increased compared to in wild-type mice (J:163043)
• total and resting energy adjusted for body weight are increased compared to in wild-type mice (J:163043)
(J:163043)
(J:163043)

muscle
(J:163043)
(J:163043)

pigmentation
(J:163043)
(J:163043)

integument
(J:163043)
(J:163043)

Mouse Models of Human Disease
OMIM ID Ref(s)
Prader-Willi Syndrome; PWS 176270 J:163043


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory