Mouse Genome Informatics
ot
    Htr2ctm1.1Eme/Y
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: on a predominantly 129S6/SvEvTac background,10% to 20% of mice die between P21 and P24
• Background Sensitivity: in a cross with a C57BL/6J male, 75% of mice die between P8 and P12 with none surviving beyond P15
• however, mortality can be minimized by feeding wet food paste on a predominantly 129S6/SvEvTac background

behavior/neurological
• gastric milk content is decreased compared to in wild-type mice
• in adult mice when food consumption is corrected for weight
• in weanlings (P2-P28) but not adults on a rotarod
• in weanlings (P2-P28) but not adults

growth/size/body
• at P21 despite normal birth weight
• mice fail to thrive after birth
• however, mice exhibit normal growth rate after weaning

homeostasis/metabolism
• total and resting energy adjusted for body weight are increased compared to in wild-type mice

muscle

pigmentation

integument

Mouse Models of Human Disease
OMIM IDRef(s)
Prader-Willi Syndrome; PWS 176270 J:163043