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Phenotypes Associated with This Genotype
Genotype
MGI:4830460
Allelic
Composition
Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd2-cre)ER44Gsat/0
Tg(Drd2-EGFP)S118Gsat/0
Genetic
Background
involves: C57BL/6 * FVB/N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r1btm5.1Pggd mutation (0 available); any Ppp1r1b mutation (18 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
Tg(Drd2-EGFP)S118Gsat mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological
• haloperidol-induced catalepsy is strongly reduced
• in an open-field test


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory