Phenotypes Associated with This Genotype

Genotype
MGI:4830456

• Allelic Composition: Mafb^kr/Mafb^kr
• Genetic Background: CBA.Cg-Mafb^kr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

inner ear cyst ( J:5392 )

• mice with cysts also have have rudimentary semicircular canals

abnormal otic vesicle development ( J:5392 )

• the expected flattening of the caudolateral wall is not seen at E11

abnormal semicircular canal morphology ( J:5392 )

• the majority of mutant mice have rudimentary canals and also cysts although the condition may not be bilateral

abnormal endolymphatic duct morphology ( J:5392 )

• a large endolymphatic space unassociated with a stria vascularis or an endolymphatic duct and sac is seen in mature mutant mice

absent endolymphatic duct ( J:5392 )

• at E12 otic vesicles of mutant mice lacked an endolymphatic duct

cellular

abnormal cell cycle ( J:5392 )

• at E11 the cell cycle time of a developing otocyst is shorter than that seen in a heterozygous littermate or a CBA/J mouse

abnormal cell cycle checkpoint function ( J:5392 )

• at E11 the premitotic phase of a developing otocyst is longer than seen in a heterozygous littermate or CBA/J mouse

growth/size/body

inner ear cyst ( J:5392 )

• mice with cysts also have have rudimentary semicircular canals