Phenotypes Associated with This Genotype

Genotype
MGI:4830336

• Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to parasitic infection ( J:163761 )

• after second infestation to ticks, mice fail to exhibit resistance (repletion) unlike similarly treated wild-type mice

• however, transfer of bone marrow from Kit^W-sh homozygotes restores repletion

hematopoietic system

abnormal hemoglobin ( J:168556 )

• increased hemisphere hemoglobin content in mouse brains injected with phosphate buffered saline

decreased platelet aggregation ( J:165893 )

• mutants exhibit a lack of collagen-induced aggregation of platelets

cardiovascular system

hematoma ( J:168556 )

• greatly enlarged area of experimentally induced hematomas

homeostasis/metabolism

decreased platelet aggregation ( J:165893 )

• mutants exhibit a lack of collagen-induced aggregation of platelets

skeleton

skeleton phenotype ( J:197378 )

N • no effect on osteoclast size and number in tibias