Phenotypes Associated with This Genotype

Genotype
MGI:4830327

• Allelic Composition: Trim33^tm1.2Los/Trim33^tm1.2Los
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:163858 )

• embryos are not recovered after E7.5

embryo

abnormal developmental patterning ( J:163858 )

• defects in embryonic polarity and tissue patterning at E6.5

abnormal mesoderm development ( J:163858 )

• defect in mesoderm formation

decreased embryo size ( J:163858 )

• at E6.5

failure of primitive streak formation ( J:163858 )

• absent at E6.5

abnormal embryonic-extraembryonic boundary morphology ( J:163858 )

• lack a clear distinction between the epiblast and extraembryonic ectoderm

absent extraembryonic ectoderm ( J:163858 )

• expression analysis indicates absence of extraembryonic ectoderm at E5.5

abnormal proamniotic cavity morphology ( J:163858 )

• at E6.5 the proamniotic cavity is undivided

abnormal anterior visceral endoderm morphology ( J:163858 )

• abnormally broad at E5.5

• at E6.5 markers of the AVE are expanded around the epiblast

growth/size/body

decreased embryo size ( J:163858 )

• at E6.5