Phenotypes Associated with This Genotype

Genotype
MGI:4830326

• Allelic Composition: Trim33^tm1.1Los/Trim33^tm1.2Los; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:163858 )

• few embryos survive to E10

embryo

embryo phenotype ( J:163858 )

N • unlike in homozygous germline null mice, no defects are seen in the anterior visceral endoderm or the extraembryonic ectoderm

abnormal endoderm development ( J:163858 )

• expression analysis indicates an almost radial expansion of the definitive endoderm at E7.5

abnormal mesendoderm development ( J:163858 )

• duplications of anterior axial mesendoderm tissues

decreased embryo size ( J:163858 )

• seen in about 1/3 of embryos that also have a defect in primitive streak morphology

incomplete rostral neuropore closure ( J:163858 )

• at E10 the few surviving embryos display open neural folds

abnormal primitive node morphology ( J:163858 )

• expanded in surviving embryos at E8.0

• duplications of node tissues

abnormal primitive streak elongation ( J:163858 )

• about 1/3 of embryos lack an overtly elongated streak

nervous system

incomplete rostral neuropore closure ( J:163858 )

• at E10 the few surviving embryos display open neural folds

abnormal brain development ( J:163858 )

• at E10 the few surviving embryos display defective brain development

growth/size/body

decreased embryo size ( J:163858 )

• seen in about 1/3 of embryos that also have a defect in primitive streak morphology