Phenotypes Associated with This Genotype

Genotype
MGI:4830275

• Allelic Composition: Kcnq1ot1^tm1.1Ckan/Kcnq1ot1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * M. spretus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal DNA methylation ( J:163857 )

• when this allele is inherited paternally, mice exhibit altered DNA methylation at somatically acquired differentially methylated regions compared with wild-type mice

• however, histone modifications to ubiquitously imprinted genes is normal

abnormal imprinting ( J:163857 )

• when this allele is inherited paternally, mice exhibit lineage-specific relaxes imprinting of ubiquitously imprinted genes compared with wild-type mice

• however, genes imprinted only in the placenta are normal