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Phenotypes Associated with This Genotype
Genotype
MGI:4829971
Allelic
Composition
Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic
Background
B6.129P2-Capn3tm1.1Hiso
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn3tm1.1Hiso mutation (1 available); any Capn3 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Muscular dystrophy phenotypes in Capn3tm1.1Hiso/Capn3tm1.1Hiso mice

muscle
• mice exhibit split myofibers and myofibers with centrally located nuclei unlike in wild-type mice
• abnormal muscle fiber morphology increases with age

homeostasis/metabolism
• mice exhibit base line and exercise-provoked muscle degeneration unlike wild-type mice
• however, muscle regeneration in exercised mice is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/13/2017
MGI 6.11
The Jackson Laboratory