Mouse Genome Informatics
hm
    Nfkbiatm1.1Pjc/Nfkbiatm1.1Pjc
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• become sick and die at about 13 - 15 months of age

immune system
• T cells are hyperresponsive to activation induced cell death
• decreased in both percentage and absolute number
• decreased in both percentage and absolute number
• T cells derived from the lungs and peripheral lymph organs are predominantly memory T cells rather than naive T cells
• at 6 weeks of age activated T cell numbers are increases in the lungs, lymph nodes, and spleen
• T cells are hyperresponsive to in vitro activation and activation induced cell death
• splenic T cells produce more IL2 and IFNG when stimulated with a low dose of anti-CD3/CD28 antibodies
• in splenic T cells in vitro when stimulated with a low dose of anti-CD3/CD28 antibodies
• hypersensitive to LPS induced proinflammatory cytokine production
• at about 13 - 15 months of age
• at about 13 - 15 months of age
• at about 13 - 15 months of age
• at 5 to 7 months of age
• increase in anti-DNA, anti-Ro/SS-A, and anti-La/SS-B antibodies at 5 to 7 months of age
• extensive perivascular lymphocytic infiltration is seen in the pancreas, liver, lacrimal glands, salivary glands, and lungs of 3 month old mice

homeostasis/metabolism
• hypersensitive to LPS induced proinflammatory cytokine production
• at about 13 - 15 months of age
• at about 13 - 15 months of age
• at about 13 - 15 months of age

hematopoietic system
• T cells are hyperresponsive to activation induced cell death
• decreased in both percentage and absolute number
• decreased in both percentage and absolute number
• T cells derived from the lungs and peripheral lymph organs are predominantly memory T cells rather than naive T cells
• at 6 weeks of age activated T cell numbers are increases in the lungs, lymph nodes, and spleen
• T cells are hyperresponsive to in vitro activation and activation induced cell death
• splenic T cells produce more IL2 and IFNG when stimulated with a low dose of anti-CD3/CD28 antibodies
• in splenic T cells in vitro when stimulated with a low dose of anti-CD3/CD28 antibodies

cellular
• T cells are hyperresponsive to activation induced cell death

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:163686