About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4829879
Allelic
Composition
Nfkbiatm1.1Pjc/Nfkbiatm1.1Pjc
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1.1Pjc mutation (0 available); any Nfkbia mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• become sick and die at about 13 - 15 months of age

immune system
• T cells are hyperresponsive to activation induced cell death
• decreased in both percentage and absolute number
• decreased in both percentage and absolute number
• T cells derived from the lungs and peripheral lymph organs are predominantly memory T cells rather than naive T cells
• at 6 weeks of age activated T cell numbers are increases in the lungs, lymph nodes, and spleen
• T cells are hyperresponsive to in vitro activation and activation induced cell death
• splenic T cells produce more IL2 and IFNG when stimulated with a low dose of anti-CD3/CD28 antibodies
• in splenic T cells in vitro when stimulated with a low dose of anti-CD3/CD28 antibodies
• hypersensitive to LPS induced proinflammatory cytokine production
• at about 13 - 15 months of age
• at about 13 - 15 months of age
• at about 13 - 15 months of age
• at 5 to 7 months of age
• increase in anti-DNA, anti-Ro/SS-A, and anti-La/SS-B antibodies at 5 to 7 months of age
• extensive perivascular lymphocytic infiltration is seen in the pancreas, liver, lacrimal glands, salivary glands, and lungs of 3 month old mice

homeostasis/metabolism
• hypersensitive to LPS induced proinflammatory cytokine production
• at about 13 - 15 months of age
• at about 13 - 15 months of age
• at about 13 - 15 months of age

hematopoietic system
• T cells are hyperresponsive to activation induced cell death
• decreased in both percentage and absolute number
• decreased in both percentage and absolute number
• T cells derived from the lungs and peripheral lymph organs are predominantly memory T cells rather than naive T cells
• at 6 weeks of age activated T cell numbers are increases in the lungs, lymph nodes, and spleen
• T cells are hyperresponsive to in vitro activation and activation induced cell death
• splenic T cells produce more IL2 and IFNG when stimulated with a low dose of anti-CD3/CD28 antibodies
• in splenic T cells in vitro when stimulated with a low dose of anti-CD3/CD28 antibodies

cellular
• T cells are hyperresponsive to activation induced cell death

endocrine/exocrine glands

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:163686


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory