Phenotypes Associated with This Genotype

Genotype
MGI:4829847

• Allelic Composition: Atg4b^{Gt(A029E06)Wrst}/Atg4b^{Gt(A029E06)Wrst}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Balance dysfunction and either absence of otoconial crystals or presence of abnormal otoconia in Atg4b^{Gt(A029E06)Wrst}/Atg4b^{Gt(A029E06)Wrst} mice

hearing/vestibular/ear

abnormal utricle morphology ( J:163712 )

• mice exhibit an accumulation of abnormal globular substances in the utricular/saccular lumen unlike in wild-type mice

abnormal vestibular saccular macula morphology ( J:163712 )

• mice exhibit an accumulation of abnormal globular substances in the utricular/saccular lumen unlike in wild-type mice

abnormal otolith morphology ( J:163712 )

• the ololith is abnormally shaped unlike in wild-type mice

absent otoliths ( J:163712 )

• in some mice

enlarged otoliths ( J:163712 )

• in some mice

behavior/neurological

impaired coordination ( J:163712 )

• on a rotarod

impaired swimming ( J:163712 )

• severely affected mice cannot swim or float unlike wild-type mice

head tilt ( J:163712 )

• in severely affected mice

circling ( J:163712 )

• in severely affected mice

cellular

impaired autophagy ( J:163712 )

• mouse embryonic fibroblasts exhibit reduced autophagy flux compared with wild-type mice

homeostasis/metabolism

impaired autophagy ( J:163712 )

• mouse embryonic fibroblasts exhibit reduced autophagy flux compared with wild-type mice

abnormal lipid homeostasis ( J:163712 )

• the liver and skeletal muscle exhibit a decrease in LC3 (Map1lc3b) lipidation after prolonged starvation compared to in wild-type mice

nervous system

nervous system phenotype ( J:163712 )

N • mice exhibit normal central nervous system morphology