Phenotypes Associated with This Genotype

Genotype
MGI:4829780

• Allelic Composition: Tg(Col2a1-Glg1)#Brle/0
• Genetic Background: FVB/N-Tg(Col2a1-Glg1)#Brle

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal long bone epiphyseal plate morphology ( J:163721 )

• the pre-hypertrophic zone exhibits increased cell density and length compared to in wild-type mice

abnormal long bone epiphyseal plate proliferative zone ( J:163721 )

• cell density in the proliferative zone is increased compared to in wild-type mice

abnormal skeleton physiology ( J:163721 )

• extracellular matrix deposition in the epiphyseal growth plate is decreased compared to in wild-type mice

abnormal chondrocyte physiology ( J:163721 )

• mice exhibit increased chondrocyte proliferation compared to in wild-type mice