Phenotypes Associated with This Genotype

Genotype
MGI:4829528

• Allelic Composition: Tg(KRT14-Il7)1Tsk/Tg(KRT14-Il7)1Tsk
• Genetic Background: FVB/N-Tg(KRT14-Il7)1Tsk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:42565 )

• majority of mice die at less than 4 weeks of age

immune system

skin inflammation ( J:42565 )

• biopsy indicates a dense dermal infiltrate of lymphocytes through the reticular and papillary dermis and extending into the epidermis

reproductive system

infertility ( J:42565 )

• surviving mice are infertile

growth/size/body

decreased body size ( J:42565 )

• runting is evident by 2-3 weeks of age

integument

skin inflammation ( J:42565 )

• biopsy indicates a dense dermal infiltrate of lymphocytes through the reticular and papillary dermis and extending into the epidermis

alopecia ( J:42565 )

• alopecia develops on dorsal trunk skin around 3 weeks of age