Phenotypes Associated with This Genotype

Genotype
MGI:4822564

• Allelic Composition: Fndc3b^tm1Maim/Fndc3b^tm1Maim
• Genetic Background: B6.129S2-Fndc3b^tm1Maim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:163660 )

• all mice are dead by P1

• all mice delivered by caesarean section die within 15 minutes

cellular

decreased fibroblast adhesion ( J:163660 )

• mouse embryonic fibroblasts exhibit reduced cell adhesion and cell spreading with reduced stress fiber formation compared with wild-type cells

abnormal cell differentiation ( J:163660 )

• mouse embryonic fibroblasts exhibit reduced angiogenesis compared with wild-type cells

decreased fibroblast cell migration ( J:163660 )

• mouse embryonic fibroblasts in a wound healing assay exhibit reduced migration compared with wild-type cells

decreased fibroblast proliferation ( J:163660 )

• mouse embryonic fibroblasts

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:163660 )

N • newborn mice exhibit normal energy homeostasis