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Phenotypes Associated with This Genotype
Genotype
MGI:4822466
Allelic
Composition		 F2rl1tm1Bpd/F2rl1tm1Bpd
Genetic
Background		 B6.129P2-F2rl1tm1Bpd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Bpd mutation (0 available); any F2rl1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:88245 )
N
• mice show no differences in high dose (100% lethal challenge) lipopolysaccharide (LPS)-induced inflammation and lethality compared to controls
decreased susceptibility to endotoxin shock ( J:88245 )
• mice treated with hirudin, a selective thrombin inhibitor, during LPS challenge exhibit prolonged survival time and reduced IL-6 expression compared to wild-type mice treated with hirudin

cardiovascular system
cardiovascular system phenotype ( J:135087 )
N
• retinal neoangiogenesis after oxygen induced retinopathy is similar to wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory