Phenotypes Associated with This Genotype

Genotype
MGI:4822464

• Allelic Composition: S1pr3^tm1Jch/S1pr3^tm1Jch
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:133917 )

• mutants are protected from LPS lethality

homeostasis/metabolism

abnormal cytokine level ( J:133917 )

• increase in IL-1beta levels in mesenteric lymph nodes but reduced levels in the lungs after LPS challenge

immune system

abnormal cytokine level ( J:133917 )

• increase in IL-1beta levels in mesenteric lymph nodes but reduced levels in the lungs after LPS challenge

enlarged mesenteric lymph nodes ( J:133917 )

• mesenteric lymph nodes are 3 times larger than in wild-type 18 hours after LPS challenge

decreased susceptibility to endotoxin shock ( J:133917 )

• mutants are protected from lipopolysaccharide (LPS) induced lethality