Phenotypes Associated with This Genotype

Genotype
MGI:4822462

• Allelic Composition: Sphk1^tm1Rlp/Sphk1^tm1Rlp
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:133917 )

• mutants are protected from LPS lethality

immune system

abnormal cytokine level ( J:133917 )

• increase in IL-1beta levels in mesenteric lymph nodes but reduced levels in the lungs after LPS challenge

enlarged mesenteric lymph nodes ( J:133917 )

• mesenteric lymph nodes are 3 times larger than in wild-type 18 hours after LPS challenge

decreased susceptibility to endotoxin shock ( J:133917 )

• mutants exhibit a similar level of initial development of inflammation as wild-type mice in response to severe challenge with lipopolysaccharide (LPS), however attenuation of the inflammation occurs 18 hours after challenge while wild-type mice succumb to the infection

homeostasis/metabolism

abnormal cytokine level ( J:133917 )

• increase in IL-1beta levels in mesenteric lymph nodes but reduced levels in the lungs after LPS challenge