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Phenotypes Associated with This Genotype
Genotype
MGI:4822239
Allelic
Composition		 Cacng2tm1.1Suto/Cacng2tm1.1Suto
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2tm1.1Suto mutation (0 available); any Cacng2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:163184 )
N
• paired-pulse facilitation is normal
abnormal AMPA-mediated synaptic currents ( J:163184 )
• the ratio of AMPA receptor to the NMDA receptor components of the excitatory postsynaptic currents is increased compared to wild-type mice
increased miniature excitatory postsynaptic current amplitude ( J:163184 )
• the amplitude of miniature excitatory postsynaptic currents (mEPSCs) is increased compared to in wild-type mice
• however, mEPSCs frequency is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory