Phenotypes Associated with This Genotype

Genotype
MGI:4822202

• Allelic Composition: Kit^W-3Bao/Kit^W-3Bao
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:163026 )

• no mice are present at weaning despite normal heart beat in mice at E18.5

reproductive system

abnormal primordial ovarian follicle morphology ( J:163026 )

♀ • at E18.5

abnormal seminiferous tubule morphology ( J:163026 )

♂ • at E18.5, seminiferous tubules are contorted unlike in wild-type mice

abnormal male reproductive system physiology ( J:163026 )

♂ • at E18.5, spermatogenic cells fail to migrate into contorted seminiferous tubules unlike in wild-type mice

hematopoietic system

macrocytic anemia ( J:163026 )

• at E18.5

decreased erythrocyte cell number ( J:163026 )

• at E18.5

decreased hematocrit ( J:163026 )

• at E18.5

decreased hemoglobin content ( J:163026 )

• at E18.5

increased mean corpuscular hemoglobin ( J:163026 )

• at E18.5

increased mean corpuscular hemoglobin concentration ( J:163026 )

• at E18.5

macrocytosis ( J:163026 )

• at E18.5

growth/size/body

decreased fetal size ( J:163026 )

• at E16.5 and E18.5

endocrine/exocrine glands

abnormal primordial ovarian follicle morphology ( J:163026 )

♀ • at E18.5

abnormal seminiferous tubule morphology ( J:163026 )

♂ • at E18.5, seminiferous tubules are contorted unlike in wild-type mice

integument

pallor ( J:163026 )

• at E14.5, E16.5, and E18.5