Mouse Genome Informatics
hm
    l11Jus16/l11Jus16
involves: C57BL/6J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

cardiovascular system
• mice exhibit L-loop ventricles and situs inversus in the heart
• in 3 of 17 mice
• observed in 2 of 17 mutant mice
• AVSD with dextrocardia is seen in 2 of 17 mice
• AVSD with levocardia is seen in 3 of 17 mice
• mutant mice develop atrioventricular septal defects with complete penetrance and variable expressivity
• 1 in 17 mice exhibit muscular ventricular septal defect

growth/size/body
• mutant mice exhibit situs inversus in the heart

Mouse Models of Human Disease
OMIM IDRef(s)
Atrioventricular Septal Defect; AVSD 606215 J:163196