Mouse Genome Informatics
hm
    avc4/avc4
involves: C57BL/6J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

cardiovascular system
• 2 of 25 mice exhibit hypoplastic pulmonary artery
• 3 of 25 mice exhibit interrupted aortic arch
• some mutant mice develop atrial septal defects of the primum type
• all mice exhibit septal defects with expressivity varying from primum atrial septal defect to complete AVSD
• some mutant mice develop atrioventricular septal defects of the complete common atrioventricular canal type
• approximately half of affected mutants exhibit unbalanced hypoplastic right ventricle

Mouse Models of Human Disease
OMIM IDRef(s)
Atrioventricular Septal Defect; AVSD 606215 J:163196