Phenotypes for Ccn2 Tg(BGLAP-cre)1Clem MGI:4822058 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Ccn2^tm1Mga/Ccn2^tm1.1Vlcg Tg(BGLAP-cre)1Clem/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn2^tm1.1Vlcg mutation (0 available); any Ccn2 mutation (28 available)
Ccn2^tm1Mga mutation (0 available); any Ccn2 mutation (28 available)
Tg(BGLAP-cre)1Clem mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased bone mineral density ( J:163027 )

• at 1 month of age osteopenia is seen

• at 1 month of age the phenotype is similar to that in Ctgf^tm1Mga single homozygotes

• at 6 months of age males show a decrease in bone volume secondary to a decrease in trabecular number

abnormal trabecular bone morphology ( J:163027 )

• at 1 month and 6 months of age the number of trabeculae is reduced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24