Phenotypes Associated with This Genotype

Genotype
MGI:4821992

• Allelic Composition: Cdh1^tm1.1Mpst/Cdh1^tm1.1Mpst
• Genetic Background: B6.129P2-Cdh1^tm1.1Mpst

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:163273 )

• die shortly after E11.5

• tetraploid complementation allows embryos to survive to at least E13

embryo

embryonic growth arrest ( J:163273 )

• at E10.5 embryos resemble E9.5 embryos

abnormal placenta morphology ( J:163273 )

• at E10.5 the overall size of the embryonic part of the placenta is reduced compared to heterozygous littermates

abnormal placental labyrinth vasculature morphology ( J:163273 )

• mingling of embryonic and maternal blood vessels is reduced with embryonic red blood

• cells restricted to superficial layers rather than deeply penetrating into the labyrinth layer

decreased placental labyrinth size ( J:163273 )

• smaller compared to heterozygous littermates at E10.5

placental labyrinth hypoplasia ( J:163273 )

• expression analysis indicates a decrease in the number of cells in the labyrinth layer

abnormal trophoblast layer morphology ( J:163273 )

• expression analysis indicates a decrease in the number of spongiotrophoblast layer cells

pale yolk sac ( J:163273 )

• at E10.5 - E11.5, the amount of blood in the yolk sac is reduced

abnormal placenta physiology ( J:163273 )

• at E10.5 cell cycle length is increased in cells in the placenta

• at E10.5 apoptosis is increased in the labyrinth layer and the chorionic plate

integument

pallor ( J:163273 )

• at E10.5 - E11.5, the amount of blood in the embryonic tissues is reduced

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:163273 )

• mingling of embryonic and maternal blood vessels is reduced with embryonic red blood

• cells restricted to superficial layers rather than deeply penetrating into the labyrinth layer