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Phenotypes Associated with This Genotype
Genotype
MGI:4821796
Allelic
Composition		 Cd274tm2Shr/Cd274tm2Shr
Pdcd1lg2tm4Shr/Pdcd1lg2tm4Shr
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274tm2Shr mutation (2 available); any Cd274 mutation (72 available)
Pdcd1lg2tm4Shr mutation (1 available); any Pdcd1lg2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:160970 )
• mice are reported to exhibit a defect in T celll tolerance and increased immune activation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory