Phenotypes Associated with This Genotype

Genotype
MGI:4821477

• Allelic Composition: \Cd1d1^tm1Luc/\Cd1d1^tm1Luc
• Genetic Background: C.129S6-Cd1d1^tm1Luc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased blood urea nitrogen level ( J:121187 )

• BUN is elevated in pristane-inoculated mice

increased urine protein level ( J:121187 )

• proteinuria develops early and is more severe in pristane treated mice

renal/urinary system

increased urine protein level ( J:121187 )

• proteinuria develops early and is more severe in pristane treated mice

kidney inflammation ( J:121187 )

• T cells and macrophages are found in the kidney after pristane treatment

glomerulonephritis ( J:121187 )

• diffuse proliferative glomerulonephritis with fibrous crescents, glomerulosclerosis, tubular atrophy, and interstitial fibrosis in 50% of pristane treated mice

glomerulosclerosis ( J:121187 )

• in 50% of pristane treated mice

glomerular crescent ( J:121187 )

• fibrous crescents in 50% of pristane treated mice

renal interstitial fibrosis ( J:121187 )

• in 50% of pristane treated mice

renal tubule atrophy ( J:121187 )

• in 50% of pristane treated mice

immune system

increased IgG3 level ( J:121187 )

• serum levels of IgG3 isotype are significantly higher in pristane-injected mice compared to similarly treated wild-type

decreased interleukin-4 secretion ( J:121187 )

• T cells from pristane treated mice stimulated with anti-CD3 or Con A secrete less IL4

increased anti-nuclear antigen antibody level ( J:121187 )

• anti-ribosomal P Abs and anti-OJ (isoleucyl tRNA synthetase complex) Abs after pristane treatment

increased anti-double stranded DNA antibody level ( J:121187 )

• increased IgG anti-dsDNA Ab levels after pristane treatment

kidney inflammation ( J:121187 )

• T cells and macrophages are found in the kidney after pristane treatment

glomerulonephritis ( J:121187 )

• diffuse proliferative glomerulonephritis with fibrous crescents, glomerulosclerosis, tubular atrophy, and interstitial fibrosis in 50% of pristane treated mice

hematopoietic system

increased IgG3 level ( J:121187 )

• serum levels of IgG3 isotype are significantly higher in pristane-injected mice compared to similarly treated wild-type