Phenotypes Associated with This Genotype

Genotype
MGI:4821353

• Allelic Composition: Huwe1^tm1Alas/Y; Tg(Nes-cre)1Kag/0
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:152966 )

♂

nervous system

abnormal neuronal precursor proliferation ( J:152966 )

♂ • at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice

♂ • at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice

♂ • at E18.5, the length of the cycle is lengthened compared to in wild-type cells

abnormal brain morphology ( J:152966 )

♂ • brains contain ectopic cellular clusters in differentiated striatal regions unlike in wild-type mice

♂ • however, no abnormalities are observed at E15.5

decreased brain size ( J:152966 )

♂

abnormal dentate gyrus morphology ( J:152966 )

♂ • poorly developed

increased cerebral cortex cell density ( J:152966 )

♂ • the cortex exhibits an increase in cellular density and decrease in intervening neuropil compared to in wild-type mice

disorganized cerebral cortex lamination ( J:152966 )

♂ • laminar organization is altered with no clearly identifiable superficial neuron layers compared to in wild-type mice

thin cerebral cortex ( J:152966 )

♂

small cerebellum ( J:152966 )

♂ • very small

increased neuronal precursor cell number ( J:152966 )

♂ • in the germinal layers

cellular

abnormal neuronal precursor proliferation ( J:152966 )

♂ • at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice

♂ • at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice

♂ • at E18.5, the length of the cycle is lengthened compared to in wild-type cells